Asymmetrical ventricular enlargement in Parkinson's disease
Identifieur interne : 002698 ( Main/Exploration ); précédent : 002697; suivant : 002699Asymmetrical ventricular enlargement in Parkinson's disease
Auteurs : XUEMEI HUANG [États-Unis] ; Yueh Z. Lee [États-Unis] ; Martin Mckeown [Canada] ; Guido Gerig [États-Unis] ; HONGBIN GU [États-Unis] ; WEILI LIN [États-Unis] ; Mechelle M. Lewis [États-Unis] ; Sutapa Ford [États-Unis] ; Alexander I. Troster [États-Unis] ; Daniel R. Weinberger [États-Unis] ; Martin Styner [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study.
Affiliations:
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Lee</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Mckeown, Martin" sort="Mckeown, Martin" uniqKey="Mckeown M" first="Martin" last="Mckeown">Martin Mckeown</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine (Neurology), Pacific Parkinson's Research Centre, University of British Columbia (UBC), University Hospital</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Gerig, Guido" sort="Gerig, Guido" uniqKey="Gerig G" first="Guido" last="Gerig">Guido Gerig</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychiatry, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Computer Science, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hongbin Gu" sort="Hongbin Gu" uniqKey="Hongbin Gu" last="Hongbin Gu">HONGBIN GU</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychiatry, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Weili Lin" sort="Weili Lin" uniqKey="Weili Lin" last="Weili Lin">WEILI LIN</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Radiology, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Ford, Sutapa" sort="Ford, Sutapa" uniqKey="Ford S" first="Sutapa" last="Ford">Sutapa Ford</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Troster, Alexander I" sort="Troster, Alexander I" uniqKey="Troster A" first="Alexander I." last="Troster">Alexander I. Troster</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Clinical Brain Disorder Branch, National Institute of Mental Health, National Institutes of Health</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychiatry, School of Medicine, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Computer Science, University of North Carolina</s1><s2>Chapel Hill, North Carolina</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymmetry</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Asymétrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Xuemei Huang" sort="Xuemei Huang" uniqKey="Xuemei Huang" last="Xuemei Huang">XUEMEI HUANG</name></region><name sortKey="Ford, Sutapa" sort="Ford, Sutapa" uniqKey="Ford S" first="Sutapa" last="Ford">Sutapa Ford</name><name sortKey="Gerig, Guido" sort="Gerig, Guido" uniqKey="Gerig G" first="Guido" last="Gerig">Guido Gerig</name><name sortKey="Gerig, Guido" sort="Gerig, Guido" uniqKey="Gerig G" first="Guido" last="Gerig">Guido Gerig</name><name sortKey="Hongbin Gu" sort="Hongbin Gu" uniqKey="Hongbin Gu" last="Hongbin Gu">HONGBIN GU</name><name sortKey="Lee, Yueh Z" sort="Lee, Yueh Z" uniqKey="Lee Y" first="Yueh Z." last="Lee">Yueh Z. Lee</name><name sortKey="Lewis, Mechelle M" sort="Lewis, Mechelle M" uniqKey="Lewis M" first="Mechelle M." last="Lewis">Mechelle M. Lewis</name><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><name sortKey="Styner, Martin" sort="Styner, Martin" uniqKey="Styner M" first="Martin" last="Styner">Martin Styner</name><name sortKey="Troster, Alexander I" sort="Troster, Alexander I" uniqKey="Troster A" first="Alexander I." last="Troster">Alexander I. Troster</name><name sortKey="Weili Lin" sort="Weili Lin" uniqKey="Weili Lin" last="Weili Lin">WEILI LIN</name><name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name></country><country name="Canada"><noRegion><name sortKey="Mckeown, Martin" sort="Mckeown, Martin" uniqKey="Mckeown M" first="Martin" last="Mckeown">Martin Mckeown</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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